Results and Publications

OPTIMA-Main Results

On Saturday 30th May 2026, Prof Rob Stein presented the OPTIMA-main first results at the ASCO 2026 conference in Chicago. You can find a copy of the slides below:

OPTIMA - ASCO 2026 presentation

OPTIMA-prelim Results 

On Thursday 15th May 2025, Prof Rob Stein presented the OPTIMA-prelim 10-year follow up results. You can find a copy of the slides below:

OPTIMA Prelim - ESMO Breast 2025


Publications:

Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer

The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation

An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment

Value of Information Analysis of Multiparameter Tests for Chemotherapy in Early Breast Cancer: The OPTIMA Prelim Trial

Discrepancies in central review re-testing of patients with ER-positive and HER2-negative breast cancer in the OPTIMA prelim randomised clinical trial

Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others

OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer

Selecting breast cancer patients for chemotherapy: the opening of the UK OPTIMA trial

Computational approaches to support comparative analysis of multiparametric tests: Modelling versus Training.